Here you should probably find a sample of what Tripoli can help you with in your web design. Using this framework will help you maintain an symmetric look and design across multiple browsers and medium. I recommend that you read more about Tripoli if you are interested in it. Hopefully it will take care of all your needs in that department.
It is always important to consider how the design of a web page differ between different browser. All browsers have standard values for margins and padding among other things. These values do not have to be the same between different browsers. You should therefor always start by neutralize this differences. You can either do it by hand by yourself or you can use a framework like Tripoli that does it for you. You get a quick and easy result using Tripoli.Home | Ios | More | Tripoli Sample F | Introducing Tripoli | Image Gallery